The commission, which is being co-chaired by Kay Davies, professor of genetics at the MDUK Oxford Neuromuscular Centre at the University of Oxford, England, and Richard Lifton, president of The Rockefeller University in New York City, includes representatives from 10 nations. Nature Genetics 2013, 45:531-6. Boyden, L.M. Recent studies have shown that adrenal tumors that constitutively produce aldosterone—a common cause of severe hypertension—arise from single somatic mutations in a potassium ion channel that causes cell proliferation and hormone production. Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Unexpectedly, mutations in chromatin modifiers are major contributors to both congenital heart disease and autism, explaining the frequent co-occurrence of these traits. Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K, Bjornson RD, Maman Y, Wang T, Tordoff J, Carlson K, Overton JD, Liu KJ, Lewis JM, Devine L, Barbarotta L, Foss FM, Subtil A, Vonderheid EC, Edelson RL, Schatz DG, Boggon TJ, Girardi M, Lifton RP. Richards Award, International Society of Nephrology, 2007, Kornberg–Berg Lifetime Achievement Award, Stanford University, 2015, New York Academy of Medicine Medal for Biomedical Science, 2016, National Academy of SciencesNational Academy of MedicineAmerican Academy of Arts and Sciences. in biological sciences, 1975Dartmouth College, M.D., 1982Ph.D. Choi, M. et al. By developing and implementing robust exome sequencing, Lifton has provided evidence that loss of nearly every gene will have large effect on the risk of specific traits. In a study led by Dr. Richard Lifton from Yale University, these researchers recently published a paper in Nature that reported on the findings from the first large-scale sequencing analysis of congenital heart disease. Laboratory of Human Genetics and Genomics, International commission on heritable genome editing holds first public meeting, Meet the scientific leaders who are changing medicine, Peek inside our 70 biomedical laboratories, Learn more about our flexible, supportive academic programs, Learn about the breakthroughs happening every day, Hear from the world’s leading speakers and thinkers, We’ve spent 119 years perfecting the bioscience institute, Heritable genome editing technology is not yet ready for clinical use, concludes an international commission co-chaired by President Lifton, Rockefeller president Richard P. Lifton releases statement on proposed federal budget cuts to science. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. De novo mutations in histone-modifying genes in congenital heart disease. Specialized Terms: Molecular genetics of common human diseases. Chemical screens have identified macrolides that selectively inhibit mutant channels, providing new opportunities for the diagnosis and treatment of these tumors. Goh G, Scholl UI, Healy JM, Choi M, Prasad ML, Nelson-Williams C, Kunstman JW, Korah R, Suttorp AC, Dietrich D, Haase M, Willenberg HS, Stålberg P, Hellman P, Akerström G, Björklund P, Carling T, Lifton RP. Nature Genetics 2015, 47:1011-9. His lab has identified hundreds of new disease genes causing known or previously undescribed diseases. Nat. On file we have 10 emails for Richard including rli***@lbinternational.com, lifton*****@gmail.com, rli***@yahoo.com, and 7 other email addresses. Genetics; Hyperaldosteronism; Mutation; Nephrology; Lymphoma, T-Cell, Cutaneous. The pathogenesis of most human diseases, and the consequence of mutation of 80 percent of human genes, is unknown. On record we show 34 phone numbers associated with Richard in area codes such as 203, 631, 212, 718, 516, and 12 other area codes. Biochemical studies have revealed the mechanisms that regulate this balance, which explains how increased dietary potassium lowers blood pressure. richard.lifton@yale.edu. Choi, J. et al. Choi M, Scholl UI, Yue P, Björklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Åkerström G, Wang W, Carling T, Lifton RP. He trained at Brigham and Women's Hospital before starting his lab at Yale in 1993. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. These individuals collectively are associated with 6 companies in 8 cities. The common human diseases that account for the vast majority of morbidity and mortality in human populations are known to have underlying inherited components. Program. Elife 5, e20125 (2016). Nature 498, 220–223 (2013). After nearly 25 years at Yale, Richard P. Lifton moved to Rockefeller to become president last fall. Nature Genetics 2014, 46:1135-1139. Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. The lab has also developed methods to identify genes with incomplete penetrance, including new telomere maintenance genes for pulmonary fibrosis (e.g., PARN) that require inhalational exposure for disease expression; and rare mutations in SMAD6 that have low penetrance for craniosynostosis without the presence of a common BMP2 risk allele. Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. in biochemistry, 1986Stanford University, Residency, 1983–1986Chief Medical Resident, 1986–1987Brigham and Women’s Hospital, Instructor in Medicine, 1986–1990Assistant Professor, 1991–1993Harvard Medical School, Assistant Professor, 1993–1994Associate Professor, 1994–1997Professor, 1997–2016Chair, Department of Genetics, 1998–2016Director, Yale Center for Human Genetics and Genomics, 1998–2016Founder, Executive Director, Yale Center for Genome Analysis, 2009–2016Yale University School of Medicine, Investigator, 1994–2016Howard Hughes Medical Institute, Professor, 2016–President, 2016–The Rockefeller University, Homer Smith Award, American Society of Nephrology, 1998, Claude Amiel Award, International Congress of Nephrology, 1999, Novartis Award for Hypertension Research, American Heart Association, 1999, Pasarow Award for Cardiovascular Research, 2001, Richard Bright Award, American Society of Hypertension, 2002, Basic Research Prize, American Heart Association, 2002, Roy O. Greep Award, The Endocrine Society, 2003, Distinguished Scientist Award, American Heart Association, 2005 Robert Tigerstedt Award, International Society of Hypertension, 2006 A.N.