Oleanane-type triterpenoid saponins from the roots of Pulsatilla koreana and their apoptosis-inducing effects on HL-60 human promyelocytic leukemia cells. Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. Epub 2013 May 13. Evid Based Complement Alternat Med. Two new lignans from the roots of Pulsatilla koreana. Cognition-enhancing and neuroprotective effects of hederacolchiside-E from Pulsatilla koreana. Triterpenoid saponins from the roots of Pulsatilla koreana. This site needs JavaScript to work properly. Recommendation for pulsatilla koreana root extract usage levels up to: Recommendation for pulsatilla koreana root extract flavor usage levels up to. SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities. 2017. Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers. Pulsatilla koreana, owing to its anti-inflammatory effects, is used in oriental herbal medicines.The major components of the methanol extract of Pulsatilla koreana are triterpenoid compounds and bisdesmoside. 2012 Feb;40(2):452-60. doi: 10.3892/ijo.2011.1204. PubMed:SK-PC-B70M alleviates neurologic symptoms in G93A-SOD1 amyotrophic lateral sclerosis mice. Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma. Clipboard, Search History, and several other advanced features are temporarily unavailable. Oncol Rep. 2017 Feb;37(2):754-760. doi: 10.3892/or.2016.5339. SB365, Pulsatilla saponin D, suppresses the growth of gefitinib-resistant NSCLC cells with Met amplification. Treatment with a methanol extract from Pulsatilla koreana significantly inhibited LPS-induced inflammatory responses. Additionally, PKE induced apoptosis by increasing expression of cleaved PARP and caspase-3 in ATC cells. Oncol Rep. 2013 Aug;30(2):801-8. doi: 10.3892/or.2013.2517. Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana. 2018 Oct 1;2018:4128984. doi: 10.1155/2018/4128984. Nutrients. 2 In addition, the plant contains the cytotoxic unsaturated lactone protoanemonin (C 3 H 4 O 2), which is formed by the breakdown of glycoside ranunculin after injury to the plant. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Cancer . PubMed:Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma. Pulsatilla koreana is a native perennial plant growing in Korea. COVID-19 is an emerging, rapidly evolving situation. Hong SW, Jung KH, Lee HS, Choi MJ, Zheng HM, Son MK, Lee GY, Hong SS. The plant requires a well-drained, humus-rich, gritty soil and a sunny position. In Vitro Cell Dev Biol Anim. Epub 2016 Dec 28. In this study, PKE suppressed the growth of ATC cells in a dose-dependent manner. Anti-angiogenic effects of water extract of a formula consisting of Pulsatilla koreana, Panax ginseng and Glycyrrhiza uralensis. Get the latest public health information from CDC: https://www.coronavirus.gov.  |  Int J Oncol. New phenolic compounds with anti-adipogenic activity from the aerial parts of Pulsatilla koreana. The plant prefers light (sandy) and medium (loamy) soils. Anti-acne activities of pulsaquinone, hydropulsaquinone, and structurally related 1, 4-quinone derivatives. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. 2015;15(12):1011-23. doi: 10.2174/138955751512150731113242. Developmental & Reproductive Toxicity . In addition, PKE decreased the expression of hypoxia-inducible factor 1α (HIF‑1α) and vascular endothelial growth factor (VEGF) as well as inhibiting tube formation and migration of human umbilical vein endothelial cells (HUVECs). BMB Rep 45.6 (2012): 371-376. NCI CPTC Antibody Characterization Program. Epub 2018 Oct 31. Carcinogenesis. Anti-Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms. Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. eCollection 2018. Anti-Inflammatory and PPAR Transactivational Effects of Oleanane-Type Triterpenoid Saponins from the Roots of Pulsatilla koreana. SK-PC-B70M confers anti-oxidant activity and reduces Abeta levels in the brain of Tg2576 mice. Son MK, Jung KH, Lee HS, Lee H, Kim SJ, Yan HH, Ryu YL, Hong SS. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. The Journal of the Korean Academy of Periodontology 30.3 (2000): 661-674. The apoptotic effect of PKE was confirmed by diamidino-2-phenylindole (DAPI) and terminal deoxynucleotidyltransferase-mediated nick end labeling (TUNEL) assay, showing apoptotic body and DNA fragmentation. PULSATILLA KOREANA EXTRACT. Epub 2011 Sep 20. Kweon K, Ahn JO, Song WJ, Li Q, Lee BY, Chae HK, Youn HY. However, the effect of PK … SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. Antitumor effects of SB injection in canine osteosarcoma and melanoma cell lines. Complete sequence analysis and antiviral screening of medicinal plants for human coxsackievirus a16 isolated in Korea. Please enable it to take advantage of the complete set of features! 2018. Isolation of nematicidal triterpenoid saponins from Pulsatilla koreana root and their activities against Meloidogyne incognita. Screening of the anticoccidial effects of herb extracts against Eimeria tenella. SK-PC-B70M from Pulsatilla koreana improves scopolamine-induced impairments of memory consolidation and spatial working memory. LC-MS/MS method for determination of hederacolchiside E, a neuroactive saponin from Pulsatilla koreana extract in rat plasma for pharmacokinetic study. However, the effect of PKE as a cancer drug candidate has been less reported. 2017 Feb;18(1):39-59. doi: 10.2174/1389202917666160803151752. Taken together, the present study demonstrated that PKE induced apoptosis, as well as inhibiting cell growth and angiogenesis in ATC cells. Evid Based Complement Alternat Med. Epub 2013 Jun 4. 2017;2017:4198035. doi: 10.1155/2017/4198035. Anti-protozoal efficacy of medicinal herb extracts against Toxoplasma gondii and Neospora caninum. Evid Based Complement Alternat Med.  |  Antitumor activity of Pulsatilla koreana extract in anaplastic thyroid cancer via apoptosis and anti-angiogenesis. Main Anti-tumor Angiogenesis Agents Isolated From Chinese Herbal Medicines. We suggest that PKE is a potent anticancer drug candidate for the treatment of thyroid cancer. US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: extract of the roots of pulstilla koreana, ranunculaceae, cosmetic ingredient for skin conditioning. The following notes are based on the general needs of the genus Pulsatilla. It cannot grow in the shade and requires moist soil. Odor and/or flavor descriptions from others (if found). Epub 2017 Jun 1. It does not reveal its actual effects and skin compatibility. Mini Rev Med Chem. SK-PC-B70M alleviates neurologic symptoms in G93A-SOD1 amyotrophic lateral sclerosis mice. Furthermore, in vivo studies showed that PKE significantly inhibited tumor growth and weight in a mouse xenograft model. Get the latest research from NIH: https://www.nih.gov/coronavirus.  |  Hong SW, Jung KH, Lee HS, Son MK, Yan HH, Kang NS, Lee J, Hong SS. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma. 2013 Sep;34(9):2156-69. doi: 10.1093/carcin/bgt159. It also tolerates acid, neutral and basic (alkaline) soils and can grow in very alkaline soil. SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. "Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats." 2019 Jan;55(1):7-16. doi: 10.1007/s11626-018-0294-y. According to its native range, it is likely to succeed outdoors in most areas of the country. Triterpenoid saponins of Pulsatilla koreana root have inhibition effects of tumor necrosis factor-α secretion in lipopolysaccharide-induced RAW264.7 cells.
2020 pulsatilla koreana extract